Abstract
Understanding adaptation in large populations.
Highlights
For the past half-century, population genetics has been dominated by studies of molecular evolution, interpreted under the neutral theory
Conventional random drift must be negligible; diversity is instead limited by occasional drastic bottlenecks and by recurrent selective sweeps [3]
The net rate of such sporadic events is described by defining an ‘‘effective size,’’ Ne, which is much smaller than the actual census size. This effective size is only a description of the level of neutral diversity and does not tell us how random drift influences the adaptive alleles that matter to the organism
Summary
For the past half-century, population genetics has been dominated by studies of molecular evolution, interpreted under the neutral theory. This effective size is only a description of the level of neutral diversity and does not tell us how random drift influences the adaptive alleles that matter to the organism.
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