Underlying factors that may affect the treatment of Platelet-rich plasma in chronic wounds

Abstract

Platelet-rich plasma (PRP) has gained widespread usage in the treatment of various chronic wounds due to its ease of preparation and high safety profile. But not every treatment can achieve satisfactory results. The quality of PRP is based on individual biological characteristics. Autologous PRP technology is greatly affected by the patient himself. Individual responses to PRP treatment are different and will produce different therapeutic effects. Especially in patients with uncontrollable factors such as aging, diabetes, and coronary heart disease, the use of antiplatelet drugs may potentially reduce the quality of autologous platelet-rich plasma (PRP). When treating related diseases, it is important to consider the impact of factors such as age, gender, and the specific disease. Currently, many researchers are focusing on the development of allogeneic PRP technology to avoid the inconvenience of collecting autologous blood and reduce potential negative effects that may exist in the patient's disease itself. In this review, we explore the factors generally recognized in current research which influence the efficacy of PRP.