Abstract
Septins are a family of GTP-binding proteins that associate with cellular membranes and the cytoskeleton. Their ability to polymerize into filamentous structures permits them to serve as diffusion barriers for membrane proteins and as multi-molecular scaffolds that recruit components of signaling pathways. At the cellular level, septins contribute to the regulation of numerous processes, including cytokinesis, cell polarity, cell migration, and many others. In this review, we discuss emerging evidence for roles of mammalian septins in the biogenesis and function of flagella and cilia, and how this may impact human diseases such as ciliopathies.
Highlights
Uncovering the Roles of Septins in CiliaReviewed by: Barbara Zieger, University of Freiburg, Germany Alexandre Benmerah, Institut National de la Santé et de la Recherche Médicale (INSERM), France
Septins are a family of poorly-characterized filamentous GTP-binding components of the cytoskeleton that orchestrate a variety of cellular processes including cytokinesis, cell migration, cell polarity, and cell-pathogen interactions (Fung et al, 2014)
All mammalian septins contain a central GTP-binding domain, have variable N and C-termini, and the C-termini have different numbers of coiled-coil domains. Based on these features and sequence similarities, mammalian septin genes can be categorized into four subgroups (SEPT1, 2, 4, 5; SEPT6, 8, 10, 11, 14; SEPT7; SEPT3, 9, 12)
Summary
Reviewed by: Barbara Zieger, University of Freiburg, Germany Alexandre Benmerah, Institut National de la Santé et de la Recherche Médicale (INSERM), France. Specialty section: This article was submitted to Signaling, a section of the journal Frontiers in Cell and Developmental. Septins are a family of GTP-binding proteins that associate with cellular membranes and the cytoskeleton. Their ability to polymerize into filamentous structures permits them to serve as diffusion barriers for membrane proteins and as multi-molecular scaffolds that recruit components of signaling pathways. Septins contribute to the regulation of numerous processes, including cytokinesis, cell polarity, cell migration, and many others. We discuss emerging evidence for roles of mammalian septins in the biogenesis and function of flagella and cilia, and how this may impact human diseases such as ciliopathies
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