Uncoupling protein 2 in regulatory mechanisms and basical experiments

Abstract

Uncoupling protein 2(UCP2)is a proton transporter which presents in the mitochondrial inner membrane.Recent studies have found that UCP2 plays important roles in protecting mitochondria functions, reducing mitochondrial ROS generation by inducing proton leak across the inner mitochondrial membrane and promoting mild uncoupling which leading to a decrease in the mitochondrial inner membrane′s potential.Because of its antioxidant function, UCP2 has been studied in several domains.This review provides novel insights into the molecular mechanisms, by which the activity of UCP2 is regulated and describe novel findings concerning basical experiments of UCP2. Key words: Uncoupling protein 2; Mitochondria; Reactive oxygen species; Sepsis