Abstract
Obesity is a multifactorial metabolic disease resulting from behavioral and genetic factors. Obesity is linked to diabetes mellitus and hypertension, which are considered as major risk factors for chronic kidney disease (CKD); moreover, it has a direct effect on developing CKD and end stage renal disease (ESRD). Here was aimed to examine the association between uncoupling protein 2 (UCP2) gene expression and obesity in CKD patients. UCP2 gene expression was analyzed by real time polymerase chain reaction (RT-PCR) in 93 participants divided into three groups. The groups included 31 non-obese CKD patients, 31 obese CKD patients, and 31 healthy, age-matched, unrelated volunteers as a control group. UCP2 gene expression was significantly relevant when comparing the non-obese CKD and obese CKD groups to the control group (p< 0.001). No significant association was found when the groups were compared by gender; Chi-square (X2) was 2.38 and p= 0.304. A significant negative correlation was found between UCP2 gene expression and BMI in CKD (p< 0.05). These results indicate that UCP2 gene expression plays a significant role as a risk factor for obesity in CKD patients.
Highlights
Chronic kidney disease (CKD) is characterized by kidney function or structure abnormalities for more than three months with health implications
Group II included 18 males and 13 females, with a mean age of 52.8±6.3 years. Their mean body mass index (BMI) was 23.1±1.04 Kg/m2 (Tables 1 and 2) No significant association was found when the groups were compared according to gender (X2 was 2.38 and p= 0.304). (Table 1)
uncoupling protein 2 (UCP2) gene expression showed a significant association between groups I and II when compared with the control group (p< 0.001) (Table 3)
Summary
Chronic kidney disease (CKD) is characterized by kidney function or structure abnormalities for more than three months with health implications. Obesity is linked to diabetes mellitus and hypertension, which are considered as major risk factors for chronic kidney disease (CKD); it has a direct effect on developing CKD and end stage renal disease (ESRD). Was aimed to examine the association between uncoupling protein 2 (UCP2) gene expression and obesity in CKD patients. Results: UCP2 gene expression was significantly relevant when comparing the non-obese CKD and obese CKD groups to the control group (p< 0.001). A significant negative correlation was found between UCP2 gene expression and BMI in CKD (p< 0.05). Conclusions: These results indicate that UCP2 gene expression plays a significant role as a risk factor for obesity in CKD patients
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