Abstract
Abstract The stable free radical 1,1′-diphenyl-2-picrylhydrazyl and its hydrazine homolog are very potent uncouplers of oxidative phosphorylation in whole mitochondria. These molecules exhibit many of the same effects on respiratory kinetics and ATPase as does 2,4-dinitrophenol, but at low concentrations near 10 −7 M, and appear to act at a mechanistic locus common to other “true” uncouplers of oxidative phosphorylation.
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