Abstract
For the past 41 years, metal-based drugs have been widely used for the treatment of cancer [...]
Highlights
In parallel to the synthesis of coordination and organometallic compounds comprising different metals and unconventional platinum-based derivatives, researchers have worked on optimizing the mechanistic and pharmacological features of promising drug candidates [1,2]. This Special Issue is devoted to some of the latest advances in anticancer metallodrugs with a focus on unconventional anticancer agents, as well as novel activation, targeting, and delivery strategies aimed at improving their pharmacological profile
In the area of unconventional anticancer agents, Romero-Canelón et al completed an overview on key ruthenium drug candidates and the knowledge acquired during the past two decades with the aim of discussing ideas to optimize their chemical design by incorporating new concepts [11]
This review focuses on complexes comprising platinum, ruthenium, copper, and iron [13]
Summary
In the past two decades, various unconventional non-platinum metal-based agents have emerged as potential alternatives for cancer treatment. In parallel to the synthesis of coordination and organometallic compounds comprising different metals and unconventional platinum-based derivatives, researchers have worked on optimizing the mechanistic and pharmacological features of promising drug candidates [1,2]. Tinoco et al contributed a review on the significant roles that copper and iron play in the molecular pathways involved in cell proliferation and metastasis, and the evaluation of selected chelators for these metals showing promise as anticancer drugs [12].
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