Abstract
The first representatives of a new class of synthetic, amphiphilic polymerspolyethylene oxide-based (PEO-based) polymers 1−3, (see Figure 2)are introduced. These polymers are constituted in a similar way as coiled-coil-forming peptides: the polymers possess a regular repeat of apolar (A) residues in a polar (P) sequence of residues. Polymers 1−3 can thus be characterized by the formula [PAPPAPP‘]n or [PAPP‘]n, in which P stands for an ethylene oxide unit, P‘ stands for a glycate unit, and A stands for a hydrophobically modified ethylene oxide unit. The preparation of 1−3 comprises the synthesis and SnOct2-catalyzed ring-opening polymerization of 2-oxo-crown ether monomers (SS)-4, (S)-5, and (S)-6. Alternatively, polymers 1−3 have been obtained by the polycondensation of their ω-hydroxycarboxylic acid precursors. 1H NMR and 13C NMR analysis as well as electrospray mass spectrometry (ES-MS) verified the integrity of the followed synthetic route and, therefore, confirmed the regular repeat of polar and apol...
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