Abstract
Primary cutaneous large B-cell lymphoma, leg-type is the most aggressive form of primary cutaneous B-cell lymphoma. It is characterized by progressive nodules and tumors initially localized to 1 anatomic region, most commonly the legs. A 48-year-old woman with melanoderma attended the service of oral and maxillofacial surgery reporting weight loss, fever, and swelling in the lower third of the face 3 months ago, followed by episodes of improvement and aggravation. Clinical extraoral examination revealed an increase in volume in the lower third of the face, reddish, diffuse plaque, and elevated and irregular surface in the chin and submental regions, associated with bilateral superficial cervical lymphadenomegaly. The incisional biopsy of the lesion was submitted to histopathological and immunohistochemical analysis, which revealed the diagnosis of diffuse cutaneous large B-cell lymphoma leg-type. The patient is in post-chemotherapy follow-up of 2 years and 4 months without evidence of relapse of the disease.
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