Abstract
This study was done to assess the unusual CD expression in 100 cases of acute myeloid leukemia from October 2016 to April 2018. The age limit was from 3 to 50 years. Four color flow cytometry was used to diagnose the fresh aspirated bone marrow or peripheral blood sample of acute leukemia. The unusual lymphoid CD expression on myeloblasts was analyzed. Among the cases, 44% were acute myeloid leukemia, 52% of patients were of acute lymphoblastic leukemia and mixed phenotype acute leukemia was 4%. Aberrant CD expression was observed in 58% acute myeloid leukemia patients. Both aberrant CD5 and CD7 lymphoid markers expressed in acute myeloid leukemia patients were 4.2%. Aberrant CD7, CD5, cCD79a and cCD3 were in 45.8%, 33.3%, 8.3%, 8.3% of acute myeloid leukemia patients respectively. In acute myeloid leukemia, the frequency of aberrant CD expression was compared with recent international data.
Highlights
Materials and MethodsKeywords: Blood cancer; CD marker; Myeloid leukemiaCite this article: Azad AK, Khan MR, Habib ABMH, Begum M
WHO predicts that the hematological cancer patients would rise about 48% in underdeveloped countries by 2030.2-4 Acute myeloid and lymphoblastic leukemia are 42.4% of hematological cancer and the frequency of acute myeloid leukemia was 28.3% in Bangladesh.[5]
Flow cytometry of acute myeloid leukemia has shown variable antigens expressed on stem cells with infrequent co-expression of lymphoid antigens
Summary
Materials and MethodsCite this article: Azad AK, Khan MR, Habib ABMH, Begum M. Uncommon CD markers in acute myeloid leukemia. Acute myeloid leukemia generally exhibits aberrant antigen expression or coexpression in relation to normal myeloid cells. The study of aberrant CD expression in acute myeloid leukemia was observed in different parts of the world.
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