Abstract
Main observation and conclusionTwo new bis‐quinolizidine alkaloids, neopetrosiasins A (1) and B (2), possessing cis‐ and trans‐quinolizidine nuclei, one known related analogue petrosin (3) and three known xestospongins (4—6), were isolated from the South China Sea sponge Neopetrosia chaliniformis. The structures of new compounds were unambiguously determined by extensive spectroscopic and single‐crystal X‐ray analyses. In bioassay, compounds 4—6 exhibited moderate cytotoxicity against several human cancer cells.
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