Abstract
Background and purpose: Temporal lobe epilepsy is the most common focal intractable epilepsy. Uncinate fasciculus is a white fiber bundle that connects the orbitofrontal cortex with the anterior temporal lobe, and is implicated in most of the superior mental functions. There is evidence of uncinate fasciculus as a propagation pathway of seizures from temporal lobe. The aim of the study is to determine uncinate fasciculus alterations in patients with temporal lobe epilepsy, through fractional anisotropy. Methods: Thirty-three patients with temporal lobe epilepsy (10 right and 23 left) were studied. All of them were right-handed and had left hemisphere dominance for language. A 1.5 T MR imaging scanner was used to obtain diffusion tensor imaging (DTI). Fractional anisotropy of uncinate fasciculus was calculated through TBSS (Tract Based Spatial Statistics). Statistical analysis was done using IBM SPSS (v. 25). Results: Fractional anisotropy was higher in right uncinate fasciculus, regardless of epilepsy side. Right uncinate fasciculus, at the insula level, showed lower fractional anisotropy in patients with right temporal lobe epilepsy. Conclusions: Results support the evidence of uncinate fasciculus as a pathway of propagation in temporal lobe epilepsy, specially at insular level.
Highlights
Epilepsy is one of the most common neurologic disorders, affecting around fifty million people all over the world (World Health Organization, 2019)
Uncinate fasciculus is a white fiber bundle that connects the orbitofrontal cortex with the anterior temporal lobe, and is implicated in most of the superior mental functions
Fractional anisotropy of uncinate fasciculus was calculated through TBSS (Tract Based Spatial Statistics)
Summary
Epilepsy is one of the most common neurologic disorders, affecting around fifty million people all over the world (World Health Organization, 2019). UF is a major fiber tract that connects orbitofrontal cortex with anterior temporal lobe, linking rostral portions of amygdala and temporal gyri with the gyrus rectus, because of this connectivity and localization, it is considered part of the limbic system and has been implicated in emotion, memory, behavioral process patterns, social situational awareness, language (Papagno, et al, 2011) (Nomura, et al, 2013) (Von der Heide, et al, 2013), and notably in temporal lobe epilepsy as an important pathway of seizure activity spread (Kim, et al, 2011) Microstructural changes in these white matter fiber bundles are evaluated with magnetic resonance imaging by using fractional anisotropy (FA), a parameter of diffusion tensor imaging sequence. Conclusions: Results support the evidence of uncinate fasciculus as a pathway of propagation in temporal lobe epilepsy, specially at insular level
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