Abstract
We report 5-substituted uridine derivatives as novel, uncharged inhibitors of β-1,4-galactosyltransferase and chemical tools for cellular applications. The new inhibitors reduce P-selectin glycoprotein 1 (PSGL-1) expression in human monocytes. Our results also provide novel insights into a unique mode of glycosyltransferase inhibition.
Highlights
Jingqian Jiang,a Varsha Kanabar,b Beatriz Padilla,b Francis Man,b Simon C
We report 5-substituted uridine derivatives as novel, uncharged inhibitors of b-1,4-galactosyltransferase and chemical tools for cellular applications
Our results provide novel insights into a unique mode of glycosyltransferase inhibition
Summary
Jingqian Jiang,a Varsha Kanabar,b Beatriz Padilla,b Francis Man,b Simon C. We report 5-substituted uridine derivatives as novel, uncharged inhibitors of b-1,4-galactosyltransferase and chemical tools for cellular applications.
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