Abstract
Uncertainty and certainty in cellular dynamics
Highlights
In Charles Darwin’s evolutionary theory, natural selection refers to a gradual adaptation of species to its environment over long periods of time through a nonrandom process (Darwin, 1859; Beddall, 1968; Wright, 1968)
Recent works in Bacillus subtilis have shown that biological noise or randomness in transcriptional machinery is crucial for controlling cell fate decision
B. subtilis can exist in bistable states under nutrient-limited conditions, the phenotypic heterogeneity observed in the population can be controlled by the level of randomness in single cell dynamics
Summary
In Charles Darwin’s evolutionary theory, natural selection refers to a gradual adaptation of species to its environment over long periods of time through a nonrandom process (Darwin, 1859; Beddall, 1968; Wright, 1968). Recent works in Bacillus subtilis have shown that biological noise or randomness in transcriptional machinery is crucial for controlling cell fate decision. Lower concentration of ComK refers to vegetative state while higher concentration leads to competence, with an unknown threshold level switching between the states.
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