Abstract
Complex chromosomal rearrangements (CCRs) are constitutional structural rearrangements that involve three or more chromosomes with more than two breakpoints. CCR carriers have a high risk of recurrent spontaneous abortion and birth of offspring with abnormal phenotype. The Preimplantation genetic testing for structural rearrangement (PGT-SR) can reduce the miscarriage rate and improve clinical outcomes. However, the odds of normal or balanced embryo for CCR carriers is very low. There are scanty data on the effect of different types of CCR on abnormal embryo rate.
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