Abstract
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective method to cure non-malignant hematological diseases. Umbilical cord blood stem cells (UCB) are characterized by weak immunogenicity, good tolerance human leukocyte antigen (HLA) mismatch, low incidence of graft-versus-host disease and relatively fast availability. UCB can be used as the graft of allo-HSCT for patients with non-malignant hematological diseases. This article reviews the efficacy of the umbilical cord blood stem cell transplantation (UCBT) in patients with primary immunodeficiency, hereditary bone marrow failure, hereditary metabolic diseases and autoimmune diseases. Key words: Umbilical cord blood; Stem cells; Transplantation; Non-malignant diseases
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