Abstract
Since the success of the first umbilical cord blood (UCB) transplantation in a child with Fanconi anaemia in 1989, great interests have emerged for this source of stem cells. UCB provides an unlimited source of ethnically diverse stem cells and is an alternative for bone marrow (BM) and peripheral blood (PB) haematopoietic stem cell transplantation (HSCT). Thus, UCB and manipulated stem cells are now collected and banked according to international accreditation standards for listing on registries allowing rapid search and accessibility worldwide. This work aims to identify problems limiting the creation of a Moroccan cord blood bank and to highlight opportunities and issues of a new legislation promoting additional applications of cell therapy.
Highlights
Umbilical Cord Blood transplantation (UCBT) was first reported in 1989 by Gluckman E. et al [1] and umbilical cord blood (UCB) is routinely used as a source of Haematopoietic Stem Cells (HSC)
The major advantage of this source is the acceptable degree of human leukocyte antigen (HLA) mismatch compared to bone marrow (BM)
UCB contains one log less nucleated cells than BM and Peripheral Blood (PB), UCB units are successfully used in transplantation of patients with myeloid and lymphatic leukemia, lymphoma, myelodysplasia, aplastic anaemia, haemoglobinopathies, thalassaemia, immune deficiency, autoimmune and inherited metabolic diseases, and other diseases especially in children [1,2,3,4,5,6,7,8]
Summary
Umbilical Cord Blood Banking for Transplantation in Morocco: Problems and opportunities. Since the success of the first umbilical cord blood (UCB) transplantation in a child with Fanconi anaemia in 1989, great interests have emerged for this source of stem cells. UCB provides an unlimited source of ethnically diverse stem cells and is an alternative for bone marrow (BM) and peripheral blood (PB) haematopoietic stem cell transplantation (HSCT). UCB and manipulated stem cells are collected and banked according to international accreditation standards for listing on registries allowing rapid search and accessibility worldwide. This work aims to identify problems limiting the creation of a Moroccan cord blood bank and to highlight opportunities and issues of a new legislation promoting additional applications of cell therapy
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