Umbilical artery serum chitotriosidase concentration in pregnancies complicated by preeclampsia and relationship between chitotriosidase levels and fetal blood flow velocity

Abstract

Objective: To evaluate the significance of umbilical cord chitotriosidase concentrations in pregnancies with mild preeclampsia and explore the relationship between fetal chitotriosidase levels and fetal blood flow velocity. Method: The study population included control group (n = 40) and study group with mild preeclampsia (n = 40). Umbilical cord blood samples were collected immediately after delivery. Umbilical artery (UA) flow velocity waveform was determined just before delivery. Results: Umbilical cord chitotriosidase levels and UA S/D rate were significantly high in preeclamptic group. Conclusion: Chitotriosidase may be useful biochemical marker of fetal compromise that reflects the severity of fetoplacental blood flow resistance in pregnancies complicated by preeclampsia.