Abstract
Aim: The purpose of this study was to characterise C<sub>60</sub>-poly(vinylpyrrolidone) (PVP) dispersions, to analyse the cutaneous absorption of fullerenes as well as to evaluate whether UVA radiation (UVA-R) could modify its permeation profile. Methods: Dispersions were characterised according to their pH, particle size, zeta potential, and morphology. Skin absorption studies were performed using porcine or human skin under UVA or sham irradiation. Results: The C<sub>60</sub> aggregate size was 129 ± 54 nm (as determined by nanoparticle tracking analysis) and the zeta potential was -4.93 ± 1.72 mV. The C<sub>60</sub> aggregates presented an irregular shape (as measured by transmission electron microscopy) and permeated through human and porcine skin. Conclusions: C<sub>60</sub>-PVP aggregates were adequately characterised. Human skin was less permeable than porcine skin, and the presence of UVA-R increased the C<sub>60</sub> content up to the dermis.
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