Abstract
The mesenchymal tissues of the human amnion were studied in specimens of 8 to 26 weeks' menstrual age. At 8 weeks the mesenchymal cells formed a continuous layer on the chorionic aspect of the amnion. Following the approximation of amnion and chorion, however, the cells became separated and were eventually dispersed in the deeper part of the mesenchyme. In the youngest specimens most of the cells exhibited evidence of considerable differentiation and contained a highly developed endoplasmic reticulum. The reduction in the frequency of such cells in the older specimens was associated with the appearance of a variety of forms thought to represent transitional stages between mesenchymal cells and Hofbauer cells. The morphologic features of the Hofbauer cells and the transitional forms were discussed in relation to the view that the Hofbauer cells are degenerated elements rather than the macrophages of the mesenchyme.
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