Abstract

An ultrastructural study of a lung specimen obtained by needle biopsy from a thirty-five month old child with idiopathic pulmonary hemosiderosis revealed a break in the continuity of the basement membrane of an alveolar capillary. Efforts to implicate an autoimmune reaction as the cause for basement membrane lysis were unsuccessful: the levels of total serum complement and serum immunoglobulins were normal; no antibodies to normal lung, desoxyribonucleic acid (DNA), extractable nuclear antigen (ENA) or milk proteins Were identified; and no deposits of protein on capillary basement membrane were observed by electron microscopy.

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