Abstract
The interrelationship between non-Hodgkin’s lymphoma (NHL) and leukemia has been discussed with regard to both clinical and histopathologic findings. Obviously there is a certain overlap and vagueness of terminology; this is due not only to different approaches to diagnosis and the different kinds of material submitted for examination but also to inherent pathophysiologic difficulties. By definition, an increase in neoplastic cells in peripheral blood is leukemia. With the use of new techniques to enrich certain cell fractions of peripheral blood, the line separating leukemic blood pictures from nonleukemic ones has become arbitrary, because the presence of even one neoplastic cell in peripheral blood means an increase, without being a leukemic blood picture. Therefore an increase of abnormal cells to more than 4000/mm3 (3500–6000/mm3) in adults is, by definition, leukemia.
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