Abstract
Nitrogen Mustard-N-Oxide was given to six guinea pigs intraperitoneally, and morphological changes of the outer hair cells in the cochlea were investigated with electron microscopy. The results obtained were as follows:1. Swelling of the cytoplasma of the cuticle free area at the top of the cell was found in various degrees. In some of them, cuticular plate was covered and the auditory hairs were partially surrounded by the swelled cytoplasma.2. Formation of double membranes was found. The double membranes were parallel to the cytoplasmic membrane, or whorl of the membranes was made in the cytoplasma.3. A rod-shaped structure was presented in a large number of the cells.4. No vacuolization was observed in any case.5. With the increase of degeneration, the outer hair cell became atrophic, then it was destroyed and disappeared, while the supporting cells were remarkably swollen.
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