Abstract
Objective: Our objective in this study was to investigate the ultrastructure of endothelial and muscle cells of human umbilical vessels in both normal and pre-eclamptic pregnancies.Methods:Ten umbilical cords from pre-eclamptic (36, 38 and 40 weeks) and four from normal pregnancies (40 weeks) were collected immediately after vaginal deliveries. Umbilical veins and arteries were isolated andfixed in phosphate-buffered 2.5% glutaraldehyde solution (pH 7.2) for 4 h and postfixed with 1% osmium tetroxide at 4°C for 2 h. The sections were embedded in Araldit CY 212. Ultrathin sections werestained with uranyl acetate, examined and photographed.Results: Human umbilical vessel endothelial cells showed ultrastructural changes in pre-eclamptic patients. Weibel–Palade bodiesand some organelles such as rough endoplasmic reticulum were found in increased numbers in venous endothelial cells. Accumulations of granular material were detected under the venous endothelium.Conclusion:The endothelial and muscle cells of the umbilical vessels from pregnancies complicated by pre-eclampsia showed morphological changes.
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