Abstract
Chronic inhalation exposure to aerosolized CdCl2 increases the incidence of lung tumors in rats. For the present study small numbers of rats and hamsters were derived from the experimental groups of a longterm inhalation study with CdCl2, CdSO4, CdO and CdS. The goal of our LM, SEM and TEM investigations was to collect detailed observations on fibrotic, hyperplastic, and preneoplastic alterations of lung tissue occurring during this experiment.Immediately after sacrifice, the lungs of the animals were fixed by intratracheal instillation of Karnovsky fixative. Tissue samples were collected from the right middle lobe of the lung. For TEM the samples were postfixed with OSO4 and routine embedded in Epon. For SEM the tissue was CPD dried, mounted on Al-stubs and sputtered with Au.Exposure to all Cd compounds caused a significant increase in tumor incidence in rats but not in hamsters. In both species a multifocal alveolar bronchiolization and a generalized thickening of the alveolar septa were observed.
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Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
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