Abstract
Globoid cells are large, frequently multinucleated, macrophages with a characteristic ultrastructural appearance which develop in the white matter of the nervous system in human globoid cell leucodystrophy (Krabbe's disease). The present light and electron microscopic study demonstrates that experimental globoid cells, morphologically indistinguishable from those occurring in the spontaneous human disease, can be produced in the rat by intracerebral injection of cerebrosides. Current concepts on the pathogenesis of globoid cell leucodystrophy are discussed in relationship to this finding.
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