Abstract
Objective To study the relationship between the ultrasturcture changes and pathogenesis of refractory epilepsy with cortical dysplasia.Method To analyze the clinical data of 7 cases of refractory epilepsy retrospectively.The electron microscope was used to observe specimens of brain tissue got from surgical excision.ResultsMacrogyria,gray matter heterotopia,cortex underdevelopment and cortex derangement were observed in the brain tissue of refractory epileptic patients with cortical dysplasia.The electron microscopic examination showed nerve tissue degeneration,decreased or increased number of neurons,swelling astrocytes,synaptic number changes,increased presynaptic terminal round clear excitatory transmitters.Conclisions Ultrastructural pathological changes including less neurons,pyknosis and degeneration,cortex architecture disorders,changes of synaptic numbers and structures could be found in dysplasia cortex of refractory epilepsy patients. Key words: Cortical dysplasia; Refractory epilepsy; Ultramicropathology
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