Abstract
This chapter investigates the origin of the nerve fibers innervating the pineal gland, particularly the nature of the granular vesicles present in the nerve endings. For this purpose, two principal approaches are used: some rats are submitted to the bilateral extirpation of the superior cervical ganglia and some are submitted to the action of drugs that may alter the metabolism of catechol and indolamines. In both cases, the glands are fixed and studied under the electron microscope, and the changes occurring in the nerve fibers and endings are recorded. Preliminary determinations of 5-hydroxytryptamine (5-HT) content are also carried out in normal and denervated glands and in some of the rats treated with agents that may change the content in this indolamine. The chapter presents the results in an extended form. The chapter discusses the actions of other drugs, such as dopamine (DOPA) 5-hydroxytryptophan (5-HTP), α-methylmetatyrosine, aramine, and nialamide on the ultrastructure of nerve endings and on the 5-HT content of the gland.
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