Abstract
Polychlorotrifluoroethylene (POLYCTFE) existing as oligomers of 3 and 4 units, is a candidate base stock for a nonflammable hydraulic fluid for advanced aircraft. POLYCTFE caused significant changes in the livers of rats after repeated inhalation exposure. Ultrastructural studies of the livers from rats exposed to vapors of POLYCTFE oligomers for 90-days revealed an increase in the number of peroxisomes, dose-dependent mitochondrial swelling and a dose-dependent increase in smooth endoplasmic reticulum. The objective of this study was to ultrastructurally examine hepatocytes from the livers of primates exposed to POLYCTFE and compare the exposed primate hepatocytes to those from rat livers, in order to determine the relevance of the effect of POLYCTFE on rat livers to human livers.Male rhesus monkeys weighing 8 to 10 kg were dosed by gavage daily for 15 days with 0.725.g/kg POLYCTFE. Four animals received POLYCTFE and 3 received a comparable amount of water.
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