Abstract
Although the ultrastructural features of several brain tumor cells have been studied in details, theultrastructure of glioma stem cells/progenitors cells (GSPC) has rarely been reported. In this paper, theauthors describe the ultrastructural features of GSPCs isolated from both a glioma tissue and the humanglioma cell SHG-44 cell line. The ultrastructural features of the two kinds of GSPCs were similar, withrelatively developed mitochondria, Golgi apparatuses, ribosomes, undeveloped rough endoplasmicreticula, seldom lysosomes and no typical autophagosomes, and high nuclear–cytoplasmic ratio. Theirnuclei, frequently containing huge amounts of euchromatin and a small quantity of heterochromatin,were mostly globular; and the majority of the nuclei had only one nucleole. Typical apoptotic cells couldhardly be found in tumor spheres, and between adjacent cells there were cell junctions, which probablywere incompletely developed desmosomes or intermediate junctions. In conclusion, their ultrastructuralfeatures showed that GSPCs were at the primary stage of differentiation, and could even partially revealthe underlying reasons for the malignant proliferation and differential inhibition of GSPCs.
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