Abstract
Ultrastructural changes in rat cardiomyocytes were studied after single administration of cyclophosphamide in the therapeutic dose. The major signs of cyclophosphamide-induced damage to cardiomyocytes included moderate lysis of myofibrils, dilation of vesicles in the granular and agranular sarcoplasmic reticulum, and destruction of mitochondria with the formation of myelin-like residual bodies. Ultrastructural changes in cardiomyocyte nuclei primarily manifested in variations of the shape, deep invaginations of the nuclear membrane, and translocation into the subsarcolemmal region.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
