Abstract
IntroductionCell‐free and concentrated ascites reinfusion therapy (CART) is used for the treatment of diuretic‐resistant ascites. An increase in circuit pressure and clogging of the filtration membrane often occur in CART for malignant ascites.MethodsTo clarify the precise mechanism of filter clogging, we performed an ultrastructural observation study of the filtration membrane after the filtration of malignant ascites.ResultsThe deposition on the filtration membrane was composed of blood cells, fibrin, or both. Cellular deposition was associated with a greater number of blood cells in the original ascites fluid. In contrast, fibrin deposition was associated with higher levels of interleukin‐6, α1‐antitrypsin, haptoglobin, and fibrinogen/fibrin degradation products.ConclusionOur results suggest that the specific pathophysiologies of malignancy (such as inflammation or coagulation/fibrinolysis) and characteristics of malignant ascites (highly concentrated and cell‐rich) are associated with clogging of the filtration membrane during CART.
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Schedule a callMore From: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
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