Abstract
The sperm-specific serine proteinase, acrosin, plays an essential though as yet undefined role in mammalian fertilization (1). Located within the acrosome as its zymogen form proacrosin, active acrosin is produced following the acrosome reaction (2) or other disruption of the sperm head membranes (3). Early evidence suggested that acrosin played an essential part in zona penetration (4). In particular the enzyme was believed to be located on the inner acrosomal membrane, where it remained to act after the rest of the acrosomal contents had been released following the acrosome reaction. However we have recently obtained indirect biochemical and immunocytochemical evidence to suggest that proacrosin is localized in the acrosomal matrix and not on the inner acrosomal membrane (5).
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