Abstract
We examined the effects of a single dose of cocaine (Coc) on the myocardium of rats fed copper sufficient (CuS) compared to copper deficient (CuD) diets. Weanling males were fed either CuS (n=13) or CuD (n=12) for 7 weeks. Ten in each group, (paired for Cu status), were injected (ip) with Coc-HCL (80-90mg/kg bw), 5 served as controlsRats which survived for 15 minutes were killed and heart tissue was obtained for light and transmission electron microscopy as well as Cu analysis. Tissue for ultrastruetural study was fixed in Carson’s fixative and post fixed in osmium tetroxide.Myocardial foci showed necrosis, fibrosis, and inflammation in all rats given cocaine but were more severe in the CuD group. CuS controls (no Coc) showed no similar lesions. Ultrastructurally the myocardium confirmed the light microscopy findings and showed apparent increase in the number of mitochondria which were of variable sizes and shapes. Giant mitochondria, clumping and foci of molding were observed. Crystalline configurations of cristae were also seen.
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