Abstract
Electron microscopic examinations of the livers of rats with the previously described galactosamine-induced hepatitis showed after 1 day extensive hypertrophy of the smooth endoplasmic reticulum, glycogen depletion, liposomes and larger fat droplets, mitochondrial irregularities, large cytoplasmic vacuoles containing serum proteins, and decreased numbers of ribosomes with nucleolar changes. It is a model of hepatic injury in which every cell is affected, but focal accentuation of the injury accounts for the light microscopic appearance of spotty necrosis. Despite the light microscopic similarity to human viral hepatits, electron microscopic changes are different in the two conditions. Part of this dissimilarity may reflect species differences and part differences in the pathogenetic mechanism. Although elevations of direct-reaction serum bilrubin are found, electron microscopic evidence of cholestasis is absent.
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