Abstract
Decreased extracellular calcium in the heart reduces cell-cell adhesion and increases intermembrane spacing in the intercalated disc (ID), particularly within the gap junction adjacent nanodomain known as the perinexus. Disruption of cell-cell adhesion within the perinexus slows cardiac conduction and can lead to arrhythmias. It is unknown whether the perinexus contains calcium-handling proteins or what mechanism(s) may locally regulate calcium levels within these ID nanodomains. L-type calcium channels (Cav1.2) located in T-tubules are the primary mediators of calcium influx and subsequent calcium-induced calcium release from the sarcoplasmic reticulum.
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