Abstract
Because splenomegaly in humans is generally investigated at advanced stage, little is known about the relationship between the change in portal pressure and the pathological characteristics of splenomegaly or the pathological features of splenomegaly in the early stage. To clarify the relationship between the development of splenomegaly and portal hypertension, a morphological study on splenomegaly induced by portal hypertension was performed mainly by scanning electron microscopy (SEM) in liver cirrhotic rats.Male Wistar rats, weighing 200 to 250 g, were used in this study. Liver cirrhosis was produced by intraperitoneal injections of 4% thioacetamide (TAA) in saline according to the previous report. Rats were divided into 5 groups (n=5 for each): groups 1 to 5 corresponding to 20, 40, 60, 80, and 100 injections of TAA, respectively. As a control for each experimental group, rats were injected with saline instead of TAA. The injection needles were placed in the portal vein trunks and abdominal aorta.
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Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
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