Abstract
Methapyrilene is a liver carcinogen in rats and induces mitochondrial proliferation in rat liver, but appears to have no genotoxic or other effects that can be related to its carcinogenic action. A number of structural analogs of methapyrilene were administered to rats and the livers were examined for ultrastructural changes similar to those induced by methapyrilene. Only one analog, methafurylene, produced a small but not significant increase in mitochondria. Pyrilamine, which has not induced liver tumors in rats, produced no detectable changes visible in the electron microscope. The nongenotoxic liver carcinogen nitrosodiethanolamine did not induce mitochondrial proliferation in rat liver. In Syrian hamsters and guinea pigs methapyrilene did not induce ultrastructural changes in the liver comparable with those seen in rats and this compound has not induced tumors in these species. The ultrastructural changes induced in rat liver by methapyrilene seem, therefore, to be unique to this compound.
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