Abstract
As examined under the electron microscope, the gastric mucosal cells of normal dogs and of dogs frozen once and killed 24 hr post freeze exhibited no significant ultrastructural differences between them. Definite ultrastructural changes did, however, appear in the parietal cells of dogs whose stomachs had been frozen once a month for 16 months. These changes involved the mitochondria and/or the endoplasmic reticular network of vesicles and intracellular canaliculi, with one type of change usually predominating in a single cell. Surface cells, mucous neck cells and zymogenic cells, on the other hand, exhibited no evidence of any significant changes as compared with those of the control animals. No correlation between extensive morphologic changes in the parietal cell and any lessening of acid secretion could be established. Whatever the ultimate implications, our investigations present definite ultrastructural evidence that the gastric parietal cell is selectively susceptible to repeated, controlled cryogenic injury.
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