Abstract
The dimensions of postsynaptic densities (PSD) of axodendritic synapses in the sensorimotor region of the rat neocortex were determined following multiple paired microiontophoretic applications of L-glutamate (Gl) and noradrenaline (NA) using electron microscopy. It was established that combined applications of Gl and NA induce a statistically significant increase in the thickness of the PSD. In this case, the intensity of the structural changes depends on the delay time (within the range of 0–5 sec) of NA action in relation to Gl. The strongest modification in PSD was observed whenever the second neurochemical signal was received at the amount of cessation of the neuronal response to the action of the first transmitter.
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