Abstract
SUMMARY Biopsies of skin lesions in different stages of evolution were taken from two patients with pemphigoid and studied by electron microscopy. Early cytoplasmic changes in the basal keratinocytes and supralaminar cleavage were seen. In the germinative cells of the regenerating skin of the blister floor in the older lesions, an inversion of the polarity of the Golgi apparatus was observed. The findings are discussed and compared with those observed in dermatitis herpetiformis. It is suggested that the pathomechanism of the early dermo-epidermal cleavage may be similar in both diseases.
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