Abstract
The method of electron microscopy and morphometry have been used to study peculiarities in formation of the structure of human embryo and fetus brain synapses at early stages (7 to 12 weeks) of development at mother alcoholization. Electron microscopy of material obtained from alcoholic women has shown slowing-down of formation of synaptic structure. Morphometry has revealed that under the influence of prenatal alco holization the formation of components of synaptic brain contacts slows down at 9—12 th weeks of development: the area of presynaptic terminals and their perimeter decreases, and the perimeter of postsynaptic densities decreases as well.
Highlights
Ultrastructural and morphometrical peculiarities of embryo and fetus brain synaptogenesis under conditions of prenatal ethanol exposure
Electron microscopy of material obtained from alcoholic women has shown slowing-down of formation of synaptic structure
Для анализа брали по пять случаев из каждого воз растного периода в контрольной и основной группах эмбрио нов
Summary
Методами электронной микроскопии и морфометрии изучены особенности формирования структуры эмбриональных синапсов моз га эмбрионов и плодов человека на ранних стадиях (7—12 нед) развития при алкоголизации матери. При морфо метрии показано, что под влиянием пренатальной алкоголизации на 9—12-й нед развития происходит задержка формирования компо нентов синаптических контактов мозга: выявлено снижение площади пресинаптических терминалей и их периметра, а также уменьшение периметра постсинаптических уплотнений. The method of electron microscopy and morphometry have been used to study peculiarities in formation of the structure of human embryo and fetus brain synapses at early stages (7 to 12 weeks) of development at mother alcoholization. Electron microscopy of material obtained from alcoholic women has shown slowing-down of formation of synaptic structure. Цель — выявить характерные особенности синаптоге неза в головном мозге эмбрионов и плодов, развивавшихся в организме беременных женщин, употреблявших этанол
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