Abstract
A time course study of the ultrastructural and autoradiographic effects of a sublethal dose of chlorfluazuron (a benzoylphenyl urea-insect growth regulator) on sixth-instar spruce budworm, Choristoneura fumiferana, which has a stadial length of about 8 days, was conducted to understand the mode of action of benzoylphenyl ureas. The effect of the compound was evident at 48 hr but reached a dramatic level at 60 hr, and at 72 hr the larvae showed signs of recovery. Accumulation of large numbers of vesicles and loss of microvilli together with the plasma membrane plaque were characteristic effects. Vesicle accumulation could indicate blockage of material being transported outside the epidermal cell, during some stage of post-translational processing, but the exact location of the blockage was not evident. Autoradiographic studies confirmed most of the ultrastructural observations.
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