Abstract
Ultrastructural Analysis and ABR Alterations in the Cochlear Hair-cells Following Aminoglycosides Administration in Guinea Pig
Highlights
The sensory hair cells within the cochlea of the mammalian inner ear convert sounds into receptor potentials when their projecting stereocilia are deflected
Guinea pigs treated with streptomycin showed higher auditory brainstem responses (ABR) thresholds, at stimuli of 2, 8, 16, and 32 kHz, which reached up to 85 dB
It was reported that significant increase in the threshold of ABR and damage of inner hair cells (IHCs) and outer hair cells (OHCs), spiral ganglion (SG) of the cochlea of guinea pig detected by light microscope, TEM and immunohistochemical staining [20]
Summary
The sensory hair cells within the cochlea of the mammalian inner ear convert sounds into receptor potentials when their projecting stereocilia are deflected. The organ of Corti of the cochlea contains two types of hair cells (HC): inner and outer hair cells (IHCs and OHCs), which differ in function. It has been appreciated for over two decades that IHCs act as the primary receptor cells for the auditory system, the OHCs act as motor cells. Three primary factors identified with increased cochleotoxic risk are the total daily dose (in illigrams/per kilogram), the course length, and repeated courses of therapy [9,10]. The mechanisms underlying their selective toxicity to
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
