Abstract

Pathological alterations in the corneas of buphthalmic rabbits were described by biomicroscopy, seanning and transmission electron microscopy. The degree of corneal clouding correlated with the increase in corneal thickness. Intraocular pressure was highest in those buphthalmic eyes with clear corneas. Intercellular epithelial edema and bullae were present in cloudy corneas and were usually associated with subepithelial fibrosis. The epithelial basement membrane was discontinuous in these eyes. Loss of stromal transparency was due to edema and scarring. The endothelial cells formed an intact monolayer in all eyes, but the cells were reduced in number per area. In addition. Descemet's membrane was either increased in thickness or a posterior collagen layer was present.

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