Ultrasound-triggered dual-drug release from poly(lactic-co-glycolic acid)/mesoporous silica nanoparticles electrospun composite fibers.

Botao Song,Chengtie Wu,Jiang Chang

doi:10.1093/rb/rbv019

Abstract

The aim of this study was to achieve on-demand controlled drug release from the dual-drug-loaded poly(lactic-co-glycolic acid)/mesoporous silica nanoparticles electrospun composite fibers by the application of ultrasound irradiation. Two drugs were loaded in different part of the composite fibrous materials, and it was found that ultrasound as an external stimulus was able to control release of drugs due to both its thermal effect and non-thermal effect. With the selective irradiation of ultrasound, the drug carrier enabled to realize controlled release, and because of different location in fibers and sensitivity of two different kinds of drugs to ultrasound irradiation, the release rate of two drugs was different. These results indicated that ultrasound irradiation was a facile method to realize the on-demand controlled release of two drugs from the electrospun fibers.

Highlights

Study on dual-drug delivery systems has been reported to obtain improved therapeutic effects [1,2,3]
Before eating, the diabetic patients only need a small amount of insulin and cyclic adenosine monophosphate (cAMP) to control blood glucose concentration, while more insulin and cAMP are required after meals due to the significant increase of the blood glucose concentration
We presented a controllable and on-demand drug delivery system based on the dual-drug-loaded PLGA/FLU/rhodamine B (RHB)-loaded MSNs electrospun composite fibers triggered by both ultrasound and temperature

Summary

Introduction

Study on dual-drug delivery systems has been reported to obtain improved therapeutic effects [1,2,3]. The control of the release of two different drugs on-demand of dosage, duration and timing is still a big challenge [5], which is often required clinically [6, 7]. After several times of treatment, the insulin is in short supply. This problem can be solved by combining the therapeutic effects of insulin and cyclic adenosine monophosphate (cAMP), because cAMP can stimulate pancreas beta cells to secrete insulin continuously [9,10,11]. Before eating, the diabetic patients only need a small amount of insulin and cAMP to control blood glucose concentration, while more insulin and cAMP are required after meals due to the significant increase of the blood glucose concentration

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Results

Conclusion