Abstract
For selective cancer gene therapy, we have developed AG73‐labeled polyethyleneglycol‐modified liposomes (AG73‐PEG liposomes) capable of encapsulating a gene condensed by poly‐l‐lysine. The present study examined whether echo‐contrast gas‐entrapping liposomes, also known as Bubble liposomes (BLs), and ultrasound (US) exposure affect not only the cell membrane but also intracellular vesicles, and enhance the release of pDNA from endosomes into the cytoplasm to achieve efficient gene transfection. AG73‐mediated liposomal gene transfection efficiency was enhanced when BLs and US exposure were used. Furthermore, confocal microscopic analysis revealed that the BLs and US exposure promoted intracellular trafficking of the AG73‐PEG liposomes during gene transfection. Thus, the use of AG73‐PEG liposomes together with BLs and US exposure may be a promising way to achieve selective and efficient gene delivery.
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