Abstract
Herein, we report an ultrasound‐promoted enantioselective decarboxylative protonation reaction of α‐aminomalonate hemiesters 1 in the presence of chiral cinchona‐derived squaramide Brønsted bases under mild conditions, which afforded both the (S)‐ and (R)‐enantiomers of α‐amino acid derivatives 2 in excellent yields (> 90 %) and excellent enantioselectivities (up to 98 % ee).
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