Ultrasound-guided cinnamol sclerotherapy combined with radiofrequency ablation for hepatic hemangioma

Abstract

Objective To explore the effect of ultrasound-guided cinnamol sclerotherapy combined with radiofrequency ablation in the treatment of hepatic hemangioma. Methods The clinical data of 48 patients with hepatic hemangioma treated at our hospital from July, 2016 to June, 2018 were collected, and were randomly divided into a control group and a combined group, 24 cases for each group. The control group was treated with superselective intra-arterial embolization of hepatic hemangioma with pingyangmycin lipiodol emulsion, and the combined group was treated with ultrasound-guided cinnamol sclerotherapy and radiofrequency ablation. The clinical efficacies, residual hemangioma, recurrence rates, bleeding volumes, hospitalization times, and adverse reactions of the two groups were compared and analyzed. The maximum lengths and cross-sectional areas of the hemangioma before and 6 months after the treatment were compared. Results The total effective rate of after 6 months’ treatment was significantly higher in the combined group than in the control group (95.83% vs. 70.83%, χ2=5.400, P=0.020). There were no statistical differences in the maximum length and cross-sectional area of the tumors between the two groups before the treatment (both P>0.05). After 6 months’ treatment, the maximum length and the maximum cross-sectional area decreased significantly in both groups (P<0.05), and were significantly lower in the combined group than in the control group (P<0.05). The residual hemangioma, recurrence rate, and bleeding volume were significantly lower and the hospitalization time was significantly shorter in the combined group than in the control group (P<0.05). The incidence of adverse reactions was 8.33% (2/24) in the combined group, and 8.33% (2/24) in the control group, with no statistical difference (χ2=0.000, P=1.000). Conclusion Ultrasound-guided cinnamol sclerotherapy combined with radiofrequency ablation for patients with hepatic hemangioma has a significant clinical effect and a high safety, and can significantly reduce the tumor volume and recurrence rate. Key words: Ultrasound-guided; Cinnamol; Radiofrequency ablation; Hepatic hemangioma