Abstract
Introduction: Ultrasound radiation force-based methods can quantitatively evaluate tissue viscoelastic material properties. A limitation of current methods includes neglecting the inherent anisotropy nature of tissue. To explore this phenomenon, we created a phantom incorporating fibrous material that has preferential orientations. Methods: Two phantoms were made in a cube-shaped mold using a fibrous material arranged in multiple layers and embedded in porcine gelatin using two different concentrations of the gelatin (8%, 14%). Shear wave measurements were made in the phantoms at different angles by rotating the phantom, where 0° and 180° were defined along the fibers, and 90° and 270° across the fibers. Measurements were performed using a Verasonics ultrasound system equipped with a linear array transducer. Results/Discussion: The mean shear wave speeds and mean standard deviations for 8% and 14% gelatin along the fibers (0°) were (3.60 ± 0.03 and 4.10 ± 0.11 m/s) and across the fibers (90°) were (3.18 ± 0.12 and 3.90 ± 0.02 m/s), respectively. Conclusion: The fibrous gelatin-based phantoms exhibited anisotropy that could be measured using quantitative shear waves speed measurements. Increasing the gelatin percentage increases the shear wave speed and anisotropic moduli. [This study was supported by NIH grant DK092255.]
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